Khanna drew the inspiration of the series as he and the creative team of TVF (Arunabh Kumar, Amit Golani, and Biswapati Sarkar) were IIT graduates. The series star Jitendra Kumar in a principal character as Jeetu Bhaiya, as like all the TVF series and sketches featuring Kumar. He was also an ex-IIT graduate studied in Kota, and his experience made them easier for him to work in the series.[16] Khanna stated about his role, adding that, "Teaching is a very humble, underrated profession, where those who practice it are not that high up on the social ladder.t
The screenwriter Saurabh Khanna who worked on The Viral Fever's Yeh Meri Family, started the scriptwriting process of his another project for TVF.
Kota Factory was shot in colour and graded into monochrome later during post production (black-and-white). The shooting was kickstarted in January 2019 and ended within 30 days.[19] After the announcement of the series' second season being renewed, the makers started their works of writing in July 2019.[20] The team initially planned to shoot the series in March 2020, but the shooting was delayed indefinitely due to the COVID-19 pandemic lockdown in India. The makers later started the shooting process in September 2020, and was filmed across two to three months in and around Madhya Pradesh. The crew shot the series under the supervision of a special team designated as in order to observe the crew members abiding the COVID-19 protocol. In January 2021, the makers announced that the shooting of the series had been wrapped.